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DELIVER FRESH INSIGHTS MONTHLY, WITH NYCU

1 April 2026

In its early stages, “medulloblastoma” typically presents no obvious symptoms. As the tumor gradually grows, it obstructs cerebrospinal fluid flow, causing young children to experience vomiting and fainting due to elevated intracranial pressure. Often diagnosed only after emergency hospital admission, medulloblastoma is a notorious killer in pediatric wards. This malignant brain tumor that is prevalent in children, often requires emergency surgery to remove the tumor and save the pediatric patient's life. However, subsequent treatment involving multiple courses of radiation therapy and chemotherapy to eliminate residual cancer cells frequently leads to severe sequelae such as cognitive impairment, motor function damage, and secondary cancers.

Finally, a decade-long multinational research collaboration between National Yang Ming Chiao Tung University, Academia Sinica, and Institut Curie in France has unraveled the regulatory mechanisms behind the abnormal proliferation of medulloblastoma cancer cells. This breakthrough offers a novel pathway for developing targeted therapies with reduced side effects, and it is expected to decrease the frequency and dosage of radiation therapy and chemotherapy for pediatric patients ...